Endocrine Abstracts

Backround: Male hypogonadism is associated with an increased incidence of cardiovascular risk factors and approximately 25% of males suffering with coronary heart disease are hypogonadal. Few studies have assessed the impact of testosterone therapy on vascular function in hypogonadal individuals and none have investigated the weekly impact of gradually reducing testosterone concentrations on vasculature.Patients and Methods: 10 hypogonadal subjects (6 wi...

Backround: Recent research has heightened the controversy surrounding the effects of conventional hormone replacement therapy on cardiovascular risk, suggesting that use of HRT is associated with an increase in cardiovascular morbidity and mortality. Testosterone has also been associated with unfavourable cardiovascular parameters and the addition of testosterone to HRT may augment the risk of cardiovascular events in postmenopausal women.Aim: To elucida...